Phil Toozs-Hobson

Consultant Obstetrician and Gynaecologist

Telephone : 0121 607 4707

email: philip.toozs-hobson@nhs.net

Research interests
I established my major research interest on the changes in the female pelvis due to childbirth. This project is continued until March 1998 (see publications) and culminated in the awarding of my doctorate in Medicine in 2003. This theme was continued by my first research fellow who was awarded her MD for her thesis in ultrasound of the anal sphincter immediately after childbirth.

Since taking up post as a consultant I have continued to be research active and published more than 25 peer reviewed papers and over 30 published abstracts at National and International meetings. I have written invited articles & book chapters in over 6 publications. I have supervised several audits (including outcomes of TVT and infection after urodynamics) and a national survey (of current practice in UDA and compliance with a MDA directive).

I have taught Nationally and Internationally and frequently been an invited speaker at various meetings including ICS &IUGA (see page 20)

Major Research Themes

1. Detrusitol for mixed incontinence (phase IV) (MERIT trial)

2. A novel compund for sensory and motor urgency (Nitric oxide flurbuprofine) (phase II)

3. Propiverine chloride for urge incontinence (phase IV)

4. A novel Potassium channel opener for detrusor overactivity (phase II)

5. An alpha blocker for detrusor overactivity (post marketing phaseII)

6. Duloxatine for stress incontinence (phase III)

7. A novel M3 specific anticholinergic for detrusor overactivity (phase III) (STAR study)

8. Randomised placebo controlled trial of Botox? for idiopathic detrusor overactivity

9. Phase IV study of fesoterodine in the elderly

10. Phase II study of Pregabalin in post operative pain relief

11. Phase II study of a novel compound (vitamin D analogue) on detrusor overactivity

12. Phase IV study Sofia looking at fesoterodine in the elderly

1. I recently finished a 2 year follow up to a multicentre study comparing the use of SIS mesh in re-do pelvic floor surgery. The full manuscript should be submitted for publication in 2009

2. CARPET study a pilot study evaluating the feasibility of colposuspension vs anterior repair and TVT for the treatment of concurrent prolapse and stress incontinence. Manuscript submitted

3. Comparison of Spinal vs local anaesthetic for retropubic tape surgery for stress incontinence.

4. RELAX study placebo controlled RCT of Botulinum toxin A therapy in refractory detrusor overactivity.

1. Prolong study. This is a large prospective cohort study following up over 12,000 women who gave birth around 1995. This study is coordinated by the University of Aberdeen

Grants

1. Randomised placebo controlled trial of Botulinum toxin A for detrusor overactivity in women.

2. Longitudinal study of pelvic floor dysfunction and childbirth.

3. MRC grant 73379 pilot study of colposuspension versus TVT and anterior repair

for concurrent stress incontinence and anterior vaginal compartment prolapse.

4. Changes in the 3 dimensional ultrasound appearances of the urethra and anal sphincter from childbirth.

Publications

Urogynaecology training in the UK: past, present and future.
Swati Jha, Robert Freeman, Philip Toozs-Hobson and David Richmond Int J Urogynaecology 2009; 20(4) 377-3802008

Colposuspension or TVT with anterior repair for urinary incontinence and prolapse: results of and lessons from a pilot randomised patient-preference study (CARPET 1).
Tincello DG, Kenyon S, Slack M, Toozs-Hobson P, Mayne C, Jones D, Taylor D. BJOG. 2009 Sep 14.

Urinary ascites following caesarean section: An unusual presentation of bladder injury.
Hassan I, L?pez C, Gee H, Toozs-Hobson P.
Eur J Obstet Gynecol Reprod Biol. 2009 Sep 17.

Urodynamics prior to treatment as an intervention: A pilot study.
Majumdar A, Latthe P, Toozs-Hobson P. Neurourol Urodyn. 2009 Sep 3.

Has the new improved IUGA abstract format led to an improvement in the quality of abstracts reporting randomised controlled trials? C. Burton, P.Toozs-Hobson. Int Urogynecol J 2009 20 S89

Results after vaginal repair of recurrent prolapse with and without xenograft reinforcement- a randomised study.  L. Mouritsen, K Gavind, K Moller Bek, P. Toozs- Hobson Int Urogynecol J 2009: 20 S173

What is the risk of a second obstetric anal sphincter injury after a previous injury?
C Burton, S Webb, M Masood, M Parsons, S Radley, P Toozs-Hobson Int Urogynecol J 2009 20 S228

Women’s experiences of stress incontinence surgery.
Loane K, Toozs-Hobson P.Neurourol and Urodyn 2009 vol 28(7) 581

Subspecialty training in Urogynaecology. Mayne C, Cutner A, Toozs-Hobson P. The Obstetrician and Gynaecologist. 2008; 10:263-266

Mycoplasma and ureaplasma colonisation in women with lower urinary tract symptoms P. M. Latthe; P. Toozs-Hobson; J. Gray. Journal of Obstetrics and Gynaecology, Volume 28, Issue 5 July 2008 , pages 519 - 521

The effect of mode of delivery on pelvic floor functional anatomy Philip Toozs- Hobson , James Balmforth, Linda Cardozo, Vik Khullar and Stavros Athanasiou International Urogynecology Journal vol 19 p 407-16

Does the mode of delivery predispose women to anal incontinence in the first year postpartum? A comparative systematic review SJ Pretlove, PJ Thompson, PM Toozs- Hobson, S Radley, KS Khan BJOG 115:4 , P421 – 434 2008

Adjuvant materials in anterior vaginal wall prolapse surgery: a systematic review of effectiveness and complications Foon R, Toozs-Hobson P, Latthe PM. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Dec;19(12):1697-706

Roasting Chestnuts by the fire: Ramsay’s syndrome. S Kadian, P Latthe, M Afnan, P.Toozs-Hobson J Obstet Gynaecol 2008 Jan; 28 (1): 120-1

Does Preoperative urodynamics alter the management of prolapse surgery? Swati Jha, Philip Toozs-Hobson, Matthew Parsons. Journal of Obstetrics and Gynaecology. 2008 Volume 28, Number 3

Prophylactic antibiotics in urodynamics: A systematic review of effectiveness and safety: Pallavi M. Latthe, Richard Foon, Philip Toozs-Hobson Neurourology and Urodynamics – 2008 vol 27: 167 - 173

Perineal and anal sphincter trauma. Diagnosis and clinical management. J Obstet Gynaecol. 2007 Nov ;27 (8):875 Philip Toozs-Hobson

Critical Evaluation of the Efficacy and Safety of Anticholinergics in Overactive Bladder, Philip Toozs-Hobson, Pallavi Latthe European Urology Supplements 2007 Vol. 6, Issue 5, Pages 425-431

Painful bladder syndrome and interstitial cystitis Swati Jha, Matthew Parsons, Philip Toozs-Hobson, The Obstetrician & Gynaecologist 2007;9:1:34-41

The role of specialised birth plans for women with previous third or forth obstetric anal sphincter injuries (OASIS) Sara Webb, Matthew Parsons, Philip Toozs-Hobson MIDRIS Midwifery digest 2007 17:3 353-4

Direct imaging of the pelvic floor muscles using two-dimensional ultrasound: a comparison of women with urogenital prolapse versus controls. Athanasiou S, Chaliha C, Toozs-Hobson P, Salvatore S, Khullar V, Cardozo L. BJOG 2007. 114 882-8

Early results of immediate repair of obstetric third degree tears:65% are completely asymptomatic despite persistant defects in 61% Hayes J, Shatari T, Toozs-Hobson P, Bushby K, Pretlove S, Radley S. Colorectal Dis.2007 9(4):332-6

Transobturator and retropubic tape procedures in stress urinary incontineince: a systematic review and meta-analysis of effectiveness and complications Latthe PM, Foon R, Toozs-Hobson P. BJOG 2007. 114(4) 522-31

Does the Mode of delivery predispose women to anal incontinence in the first year post-partum? A comparative systematic review. Toozs-Hobson P, Pretlove S, Radley S. Int J Pelvic floor Dysfunct. 2007. Suppl1 81

How does urodynamics affect subsequent patient behaviour? Toozs-Hobson P, Majundar A, Robb K, Powles K. Int J Pelvic floor Dysfunct. 2007. Suppl1 93

Partial third degree tears. Does type of repair matter? Toozs-Hobson P, Webb S, Pretlove S, Radley S. Int J Pelvic floor Dysfunct. 2007. Suppl1 119

Patient experience of an electronic questionnaire in clinical practice. Jha S, Radley S, Toozs-Hobson P, Farkas A, Jones G. Int J Pelvic floor Dysfunct. 2007. Suppl1 244

Survey of use of local anaesthetic and vasoconstrictive infiltration in vaginal surgery. Latthe P, Kadian S, Parsons M, Toozs-Hobson P, Int J Pelvic floor Dysfunct. 2007. Suppl1 244

Current and future trends in the management of overactive bladder. Wagg A, Majundar A, Toozs-Hobson PM, Patel AK, Chapple CR, Hill S. Int Urogenital J Pelvic floor Dysfunct. 2007. 18: 81-94

Overactive Bladder: An Overview of the condition, its history and current pharmacotherapy. Majumdar A. Toozs-Hobson PM BJOG suppl 2007(1)

Prevalence of anal incontinence according to age and gender: a systematic review and meta-regression analysis. Pretlove S, Radley S, Khan K Toozs-Hobson P. 2006. International Urogynecololgy Journal and pelvic floor dysfunction, 17(4) 407-417.

Aetiology of anal incontinence in the first year after childbirth: A systematic review and meta-analysis Pretlove SJ, Radley S, Toozs-Hobson PM, Thompson PJ, Khan KS Int J Urogynaecology 2006 Parsons M. Toozs-Hobson P. The investigation and management of interstitial cystitis Journal of the British Menopause Society. 11(4):132-9, 2005 Dec.

A comparision of the efficacy & tolerability of solifenacin succinate & extended release tolterodine at treatment of overactive bladder results of the STAR trial. Chapple CR, Martinez-Garcia R, Selvaggi L, Toozs-Hobson P et al. Eur Urol 2005 48(7):464-70

Kentera: transdermal oxybutynin for urinary incontinence Robb K, Toozs-Hobson P Prescriber 19/10/05 p.51-55

Importance of evacuatory disturbance in evaluation of faecal incontinence after third degree obstetric tear Colorectal Disease 2005 Jan;7(1):18-21 Shatari T, Hayes J, Pretlove S, Toozs-Hobson P, Radley S, Keighley MR

Abdominal Sacrocolpopexy for vault prolapse without burial of mesh; a case series. Soheir Elneil, Alfred Cutner, Mary Remy, Andrew Leather, Philip Toozs-Hobson & Brian Wise. BJOG 2005, 112(4) 486-489

The safety and effectiveness of Duloxetine compared with placebo in women in the UK with stress urinary incontinence(SUI) Cardozo LD, Toozs-Hobson P, Parsons M, Cox J, Quail D, Voss S 111 vol 16 2005 Int Urogyn J

Prevelance of anal incontinence according to age and gender: A systematic review and meta-regression analysis Neurourology and Urodynamics 2005 Pretlove S, Coomarasany A, Thompson P, Radley S, Khan K, Toozs Hobson P Endoanal ultrasound immediately postpartum: Results and correlations at six weeks post-partum.Pretlove S, Thompson P, Radley S, Toozs Hobson P Neurourology and Urodynamics 2005

This page was last modified on Wed Apr 11 2012